AOR - P.E.A. Activate - 60 Lozenge(s) - NPN: 80090258 -- Palmitoylethanolamide (PEA) is a long-chain fatty acid naturally produced by the body but also found in foods such as egg yolk, soy and sunflower oils. This molecule, researched for its unique and varied health benefits for eighty years, is now receiving attention because of its crucial role in the endocannabinoid system (ECS). The ECS is a lipid communication network with critical physiological functions. It is a signaling network that communicates with other systems throughout the body, helping to regulate them. PEA is an endocannabinoid produced locally by the cells, and it accumulates in tissues following an injury, physical stress or pain.By inhibiting the activation of mast cells that cause additional inflammation (such as the release of histamine), PEA acts as a potent anti-inflammatory agent. This unique molecule has other direct and indirect mechanisms of action; it even enhances the action of other endocannabinoids through its entourage effect. The PEA molecule has been clinically demonstrated to relieve pain in osteoarthritis of the knee as well as to reduce symptoms of low back pain. This mighty little molecule is well tolerated.